Phytoestrogenic Potential of Resveratrol by Selective Activation of Estrogen Receptor-α in Osteoblast Cells

Abstract Resveratrol obtained in grape seed and skin is structurally similar to a synthetic estrogen diethylstilbestrol. The endogenous estrogen, 17β-estradiol, induces cellular responses by binding the receptor alpha beta. bone fracture due decreased mineral density postmenopausal women linked reduced estrogen. adverse drug reactions of hormone replacement therapy warrant identifying unique natural compounds with ER-subtype specificity improve health. considered phytoestrogen; however, its isoform selectivity has not yet been established on osteoblast cell lines. Therefore, vitro silico docking studies were performed analyze affinity resveratrol towards β-isoforms. was evaluated for actions proliferation differentiation primary rat calvarial osteoblasts marrow cells. Osteoblasts specifically increased expression cells; there no effect beta expression. In further confirmed specificity. observed differences orientation, interaction pattern, at active site are supported western blot analysis. mimetic action suggests therapeutic potential as anabolic agent osteoporosis.